Detection of adamantane-sensitive influenza A(H3N2) viruses in Australia, 2017: a cause for hope?

نویسندگان

  • Aeron Hurt
  • Naomi Komadina
  • Yi-Mo Deng
  • Matthew Kaye
  • Sheena Sullivan
  • Kanta Subbarao
  • Ian Barr
چکیده

For over a decade virtually all A(H3N2) influenza viruses have been resistant to the adamantane class of antivirals. However, during the 2017 influenza season in Australia, 15/461 (3.3%) adamantane-sensitive A(H3N2) viruses encoding serine at residue 31 of the M2 protein were detected, more than the total number identified globally during the last 6 years. A return to wide circulation of adamantane-sensitive A(H3N2) viruses would revive the option of using these drugs for treatment and prophylaxis.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

بررسی توالی ژن M2 ویروس‌های آنفولانزا جداشده از بیماران ایرانی در سال 1393 به‌منظور تعیین مقاومت به آدامانتان‌ها

Background and Objective: Adamantanes, amantadine, and rimantadine have been used for many years for prevention and treatment of influenza virus A infections. These drugs are influenza virus M2 protein inhibitors and some amino acids substitutions in transmembrane portion of this protein cause resistance to them. This study was done for survey of adamantane resistance related nucleotide sequenc...

متن کامل

شناسایی ویروس‌های آنفلوانزای A/H3N2 مقاوم به اسلتامیویر با تست Real-time RT- PCR

Background: Currently, with increasing risk of influenza A virus epidemics, a lot of studies have been performed. Oseltamivir or Tamiflu (the neuraminidase (NA) inhibitor) is one of the effective drugs for preventing and treatment of these viruses. The H274Y mutation is from the most important drug resistant factors in influenza A viruses. The aim of this study was detection of Oseltamivir...

متن کامل

Detection of Seasonal Influenza H1N1 and H3N2 Viruses using RT-PCR Assay during 2009 Flu Pandemic in Golestan Province

Abstract Background and Objective: The emergence of a novel H1N1influenza A virus of animal origin with transmissibility from human to human poses pandemic concern. Current subtypes of Seasonal influenza A viruses spread in human are influenza A H1N1 influenza A H3N2 and influenza type B viruses. The aim of this study was to determine current strains of the H3N2 and new H1N1 subtypes of influe...

متن کامل

Genomic events underlying the changes in adamantane resistance among influenza A(H3N2) viruses during 2006–2008

BACKGROUND Adamantanes resistance in H3N2 viruses has been increasing since 2000, and in 2005-2006 reached nearly 100% in most countries, with the circulation of the N-lineage. In 2006-2007, however, a significant decrease in resistance was observed in many regions. OBJECTIVES To explore potential links between adamantane resistance and the A(H3N2) viruses that circulated between 2006 and 200...

متن کامل

بررسی روند مقاومت ویروس‌های آنفلوانزای A/H3N2 به داروهای آدامانتین و مهار‌کننده نورامینیداز طی هشت سال در ایران

Background: Influenza viruses are one of the most important etiological agents of res-piratory disease in humans and cause epidemics and pandemics with substantial mor-bidity and mortality worldwide. Vaccination and antiviral treatments are the sole and essential way for the prevention and control of influenza infection. During an influenza epidemic before the production of effective vaccine, a...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 22  شماره 

صفحات  -

تاریخ انتشار 2017